Retinoblastoma (resulting in eye tumor) results from inactivation of Rb gene, a tumor suppressor. A).List the molecular events that lead to the development of hereditary retinoblastoma? ________________________________________________________________________________________________________________________________________________________________________________________________ B). How the development of sporadic retinoblastoma will be different from the hereditary one? Mention the molecular steps that will be unique for the sporadic retinoblastoma? _________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ C). Is the loss of Rb function dominant or recessive and why? ________________________________________________________________________________________________________________________________________________________________________________________________ D). Knowing the Rb binds to E2F, which is transcription factor activating expression of proteins involved in DNA replication, predict the cellular events (on DNA level) that will be initiated following the loss of RB. Why these events will lead to cancer (write step by step what will happen in the cell following the loss of RB and result in cancer). Explain your answers. ________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________