How does BPG, or 2,3-biphophoglycerate produce the shift in the oxygen bunding curves shown? (BPG works to effect the binding of oxygen to hemoglobin) Circle the correct choice. a) BPG binds to the R state of hemoglobin tetramer. b) BPG binds to the T state of hemoglobin tetramer. c) BPG binds to the heme group, which blocks access to the oxygen d) BPG oxidizes the iron (II) in the heme group to the iron (III), preventing oxygen from binding. 1.0 0 mM BPG 5 mM BPG 8 mM BPG in θ 0.5 0 4 8 12 16 po2 (kPa) 1.0 0 mM BPG 5 mM BPG 8 mM BPG in θ 0.5 0 4 8 12 16 po2 (kPa)
The T state of haemoglobin is referred to as the T state. Explanation: 2,3-BPG binds to deoxyhemoglobin, it acts to stabilize the low oxygen affinity state (T state) of the oxygen carrier. It decreases the affinity for oxygen and allosterically promotes the release of the remaining oxygen molecule bound to the hemoglobin when it interacts with deoxygenated hemoglobin alpha subunits.
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